BAP1 Polyclonal Antibody
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Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | Q92560 |
| Gene Id | 8314 |
| Gene Symbols | BAP1 |
| Protein Name / Synonyms | BAP1, HUCEP-13, UCHL2, hucep-6, BRCA1 associated protein 1 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.01% thimerosal, 50% glycerol, pH 7.3 |
| Recommended Applications | Western Blotting, IHC |
| Research Area | Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Background
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.
Dilutions
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IHC 1:50 - 1:200
Format
Calculated MW
80kDa
Observed MW
Refer to figures
Immunogen
Recombinant funsion protein containing a sequence corresponding to amino acids 460-729 of human BAP1 (NP_004647.1).
Modification
Unmodified
Storage
-20°C
Images
Immunohistochemistry of paraffin-embedded human breast using BAP1 antibody (144-06533) at dilution of 1:150 (40x lens).
Immunohistochemistry of paraffin-embedded human breast cancer using BAP1 antibody (144-06533) at dilution of 1:150 (40x lens).
Expiration:
12 months from the date of shipment when stored properly.