Rabbit Anti-CBS (Center) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Rat |
| Host Species | Rabbit |
| Accession Number | P35520 |
| Gene Id | 875 |
| Gene Symbols | CBS |
| Protein Name / Synonyms | CBS (Center) |
| Clonality | Polyclonal |
| Preparation | This CBS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-330 amino acids from the Central region of human CBS. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, IHC-P, IF, FC |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. This protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria.
Specificity
Predicted Reactivity
Monkey
Other Names
CBS; Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase
NCBI Accession #
NP_000062.1;NP_001171479.1;NP_001171480.1
Other Accession #
Q58H57
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
60587
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50; IF: 1:10-50; FC: 1:10-50
 | CBS Antibody (Center) (Cat# 102-17039) western blot analysis in Raji cell line, rat brain and cerebellum tissue lysates (35ug/lane).This demonstrates the CBS antibody detected the CBS protein (arrow). |
 | Formalin-fixed and paraffin-embedded human brain tissue reacted with CBS Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
 | Confocal immunofluorescent analysis of CBS Antibody (Center)(Cat# 102-17039) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue). |
 | CBS Antibody (Center) (Cat# 102-17039) flow cytometric analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.