This ABCC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 899-925 amino acids from the Central region of human ABCC3.
Host Species
Rabbit
Clonality
Polyclonal
Species
Human
Introduction
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Specificity
Other Names
ABCC3; CMOAT2; MLP2; MRP3; Canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; Multidrug resistance-associated protein 3
ABCC3 Antibody (Center) (Cat# 102-10565) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ABCC3 antibody detected the ABCC3 protein (arrow).
ABCC3 antibody (Center) (Cat# 102-10565) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCC3 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
ABCC3 Antibody (Center) (Cat# 102-10565) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
