This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
Host Species
Rabbit
Clonality
Polyclonal
Species
Human
Introduction
ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
Specificity
Predicted Reactivity
Mouse
Other Names
ABCD1; ALD; ATP-binding cassette sub-family D member 1; Adrenoleukodystrophy protein
ABCD1 Antibody (Center) (Cat# 102-10656) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ABCD1 antibody detected the ABCD1 protein (arrow).
ABCD1 antibody (Center) (Cat# 102-10656) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCD1 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
ABCD1 Antibody (Center) (Cat# 102-10656) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
