Rabbit Anti-Human ALK (Center) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9UM73 |
| Gene Id | 238 |
| Gene Symbols | ALK |
| Protein Name / Synonyms | ALK (Center) |
| Clonality | Polyclonal |
| Preparation | This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636-666 amino acids from the Central region of human ALK. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2;5)(p23;q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
Specificity
Other Names
ALK; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD_antigen=CD246; Flags: Precursor
NCBI Accession #
NP_004295.2
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
176442
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of ALK(Center)(arrow) using rabbit polyclonal ALK(Center) Antibody (Cat# 102-17444).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALK (Center) gene (Lane 2) (Origene Technologies). |
 | Formalin-fixed and paraffin-embedded human testis tissue reacted with ALK antibody (Center) (Cat# 102-17444), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.