Angiotensin II (Ang II) is the key peptide hormone in the renin-angiotensin-aldosterone system (RAAS). Its ability to regulate levels of circulating aldosterone relies on actions on adrenal glomerulosa cells. Many of the Ang II effects on glomerulosa cells involve a precisely coordinated regulation of signaling cascades and gene expression. Ang II interacts with its G protein-coupled receptor in zona glomerulosa adrenal cells and triggers a cascade of intracellular signals that regulates steroidogenesis and proliferation. It also promotes vascular smooth muscle cell (VSMC) growth, stimulates Ca(2+)- calmodulin (CaM)-dependent kinase II (CaMKII), and activates cytosolic Ca(2+)-dependent phospholipase A2 (cPLA2), which releases arachidonic acid (AA). ANG II also generates H2O2 and activates Akt, which have been implicated in ANG II actions in VSMC.

The rabbit anti-human/mouse Angiotensin II antibody detects specifically target at various concentrations in ELISA and EIA assays. Cross reactivity with rat is expected from sequence similarity

Store at -20°C. If intended for use within a month, the antibody may be kept at 4°C. Please minimize freezing and thawing cycles.

• Schorb, W., et al. 1994. Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts. J. Biol. Chem. 269: 19626-19632.
• Marrero, M.B., et al. 1995. Direct stimulation of JAK/Stat pathway by the Angiotensin II AT1 receptor. Nature 375: 247-250.
• Yayama, K., et al. 2008. Angiotensin II-induced vasodilation via type 2 receptor: role of Bradykinin and nitric oxide. Int. Immunopharmacol. 8:312-318.