Rabbit Anti-Human ARHB (Center) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P62745 |
| Gene Id | 388 |
| Gene Symbols | RHOB |
| Protein Name / Synonyms | ARHB (Center) |
| Clonality | Polyclonal |
| Preparation | This ARHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-137 amino acids from the Central region of human ARHB. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Angiogenesis |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
ARHB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
Specificity
Predicted Reactivity
Mouse, Rat, Bovine
Other Names
RHOB; ARH6; ARHB; Rho-related GTP-binding protein RhoB; Rho cDNA clone 6
NCBI Accession #
NP_004031.1
Other Accession #
P62747; P62746; Q3ZBW5; NP_004031.1
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
22123
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | ARHB Antibody (Center) (Cat# 102-11473) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ARHB antibody detected the ARHB protein (arrow). |
 | ARHB Antibody (Center) (Cat# 102-11473)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ARHB Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.