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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P51677 |
| Gene Id | 1232 |
| Gene Symbols | CCR3 |
| Protein Name / Synonyms | CCR3 (Center) |
| Clonality | Polyclonal |
| Preparation | This CCR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-318 amino acids from the Central region of human CCR3. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, FC |
| Research Area | Angiogenesis, Inflammation, Chemokine Biology |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
CCR3 is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
Specificity
Predicted Reactivity
Monkey
Other Names
CCR3; CMKBR3; C-C chemokine receptor type 3; Eosinophil eotaxin receptor; CD_antigen=CD193
NCBI Accession #
NP_001828.1;NP_847898.1;NP_847899.1
Other Accession #
Q9BDS8
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
41044
Recommended Dilutions
WB: 1:1000; FC: 1:10-50
 | Western blot analysis of CCR3 Antibody (Center) (Cat# 102-18037) in Jurkat cell line lysates (35ug/lane). CCR3 (arrow) was detected using the purified Pab. |
 | CCR3 Antibody (Center) (Cat# 102-18037) flow cytometry analysis of Jurkat cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.