Rabbit Anti-Human CLDN16 (N-term)

Rabbit Anti-Human CLDN16 (N-term) Antibody, 400 ul
In stock

Product Description


Size 400 µl
Protein Name / Synonyms CLDN16 (N-term)
Accession Number Q9Y5I7
Gene Symbols CLDN16
Gene Id 10686
Concentration (lot specific) 0.360 mg/ml
Preparation This CLDN16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-33 amino acids from the N-terminal region of human CLDN16.
Host Species Rabbit
Clonality Polyclonal
Species Human


Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.


Other Names
CLDN16; PCLN1; Claudin-16; Paracellin-1
NCBI Accession #
Other Accession #


Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50; FC: 1:10-50
CLDN16 Antibody (N-term) (Cat# 102-10648) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CLDN16 antibody detected the CLDN16 protein (arrow).
CLDN16 antibody (N-term) (Cat# 102-10648) immunohistochemistry analysis in formalin fixed and paraffin embedded human Kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CLDN16 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
CLDN16 Antibody (N-term) (Cat# 102-10648) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source



2-8°C (short-term); -20°C (long-term)
12 months from the date of shipment when stored properly.
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