Rabbit Anti-Human CLU / ApoJ

Rabbit Anti-Human CLU / ApoJ

DS-PB-00501
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Antigen Information

Protein Name & Synonyms:
CLU / ApoJ
Target Species:
  • Human

Antibody Specifications

Applications:
Immunohistology - Paraffin, Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to Clusterin were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human

This product detects a band of approximately 60kDa in human brain tissue lysate.

Specificity

This product recognizes human clusterin (also known as apolipoprotein J). Clusterin is a ubiquitous glycoprotein which exists in at least two distinct isoforms; a proapoptotic nuclear form, of 49kDa, and a prosurvival secretory form with a molecular weight of 75-80kDa. Clusterin is implicated in several diverse physiological processes including sperm maturation, cell differentiation, and apoptosis.

Clusterin upregulation has been reported in various human malignancies, including bladder, prostate, and breast tumours.

Following specific stress induced injury, secretory clusterin acts as a molecular chaperone, scavenging denatured proteins outside cells. It has been shown to be upregulated in Alzheimer's disease, retinitis pigmentosa, glomerulonephritis, atherosclerosis and myocardial infarction.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to Clusterin were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
Recombinant human clusterin isoform 1.
Preservative:
0.02%Sodium Azide (NaN3)

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.