Rabbit Anti-Human DAAM1 (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9Y4D1 |
| Gene Id | 23002 |
| Gene Symbols | DAAM1 |
| Protein Name / Synonyms | DAAM1 (N-term) |
| Clonality | Polyclonal |
| Preparation | This DAAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human DAAM1. |
| Concentration (lot specific) | 0.480 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton. Recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein.
Specificity
Predicted Reactivity
Mouse
Other Names
DAAM1; KIAA0666; Disheveled-associated activator of morphogenesis 1
NCBI Accession #
NP_001257449.1;NP_055807.1
Other Accession #
Q8BPM0
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
123473
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of DAAM1 (arrow) using rabbit polyclonal DAAM1 Antibody(Human N-term) (Cat# 102-15088). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DAAM1 gene (Lane 2) (Origene Technologies). |
 | Formalin-fixed and paraffin-embedded human brain tissue reacted with DAAM1 Antibody (N-term) (Cat# 102-15088), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.