Gastric inhibitory polypeptide (GIP), also known as the glucose-dependent insulinotropic peptide is a member of the secretin family of hormones. This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. GIP is also thought to have significant effects on fatty acid metabolism through stimulation of lipoprotein lipase activity in adipocytes.

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The antibody binds to human GIP. Cross reactivity with mouse or rat GIP was not tested.

Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilizedantibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1 month at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.

12 months from the date of shipment when stored properly.

RayBio^® Gastric Inhibitory Peptide (GIP) EIA Kit for Serum, Plasma, Culture Supernatant and Cell Lysates (cat# EIA-GIP-1)

• Meier JJ, Nauck MA. (2005). "Glucagon-like peptide 1(GLP-1) in biology and pathology". Diabetes Metab. Res. Rev. 21 (2): 91–117. Efendic S, Portwood N (2004). "Overview of incretin hormones". Horm. Metab. Res. 36 (11–12): 742–6.
• Thorens B (1995). "Glucagon-like peptide-1 and control of insulin secretion". Diabete Metab. 21 (5): 311–8.