This H2AFZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human H2AFZ.
Host Species
Rabbit
Clonality
Polyclonal
Species
Human
Introduction
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq].
Specificity
Predicted Reactivity
Mouse, Rat, Zebrafish, Bovine, Chicken, Drosophila, C.Elegans, Rabbit, Xenopus
H2AFZ Antibody (C-term) (Cat# 102-11004) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the H2AFZ antibody detected the H2AFZ protein (arrow).
H2AFZ Antibody (C-term) (Cat# 102-11004)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of H2AFZ Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
