Description
Inhibin, which belong to the TGF-beta protein superfamily, inhibits FSH production and GnRH release from the hypothalamus. Inhibins are dimeric peptide hormones produced by female ovarian granulose cells and male Sertoli cells as well as a variety of other tissues. Inhibins have two isoforms, A and B, with the same alpha subunit but different beta subunits. Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits.
Inhibins can inhibit the production of follicle-stimulating hormone (FSH) by the pituitary gland. In addition, Inhibins also play a role in the control of gametogenesis, and embryonic and fetal development. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with the protein from other species has not yet been tested.
Related Products
RayBio® Inhibin-A EIA Kit for Serum, Plasma, Culture Supernantant and Cell Lysates(Cat#EIA-INA-1)Recombinant Human Inhibin-Alpha (Cat#228-10962-3)Rabbit anti inhibin A(Alpha), RB-13-0006 Rabbit anti inhibin A(beta A chain), RB-13-0007Rabbit anti Inhibin B (beta B)-C-terminus, RB-16-0003
References
- Chen YG, et.al., (2006). Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Exp. Biol. Med. (Maywood) 231 (5): 53444.
- Myers GM, Lambert-Messerlian GM, Sigman M (November 2008). "Inhibin B reference data for fertile and infertile men in Northeast America". Fertil. Steril. 92 (6): 19203.
Expiration:
12 months from the date of shipment when stored properly.
