This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human JMJD4.
Host Species
Rabbit
Clonality
Polyclonal
Species
Human
Introduction
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Specificity
Other Names
Jumonji domain-containing protein 4; JMJD4;
NCBI Accession #
NP_001154937.1;NP_075383.2
Other Accession #
Q32M74
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
52493
Recommended Dilutions
WB: 1:1000
Western blot analysis of anti-JMJD4 (N-term) Pab in HepG2 cell line lysate. JMJD4 (N-term)(arrow) was detected using the purified Pab.
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
