Rabbit Anti-Human KIM-1 / TIM-1 / HAVCR1

Rabbit Anti-Human KIM-1 / TIM-1 / HAVCR1

DS-PB-01961
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Antigen Information

Protein Name & Synonyms:
KIM-1 / TIM-1 / HAVCR1
Target Species:
  • Human

Antibody Specifications

Applications:
Western Blotting
Concentration:
IgG concentration 1.0mg/ml
Preparation:
Antisera to human TIM-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Species Reactivity:
Human, Expected cross reactivity from sequence similarity: mouse and rat

This product detects a band of approximately 49kDa in human uterus tissue lysate.

Specificity

This product detects T cell immunoglobulin mucin-1 (TIM-1), which was first identified as the receptor used by hepatitis A for viral entry (it is also known as the hepatitis A virus cellular receptor- HAVCR). TIM-1 is a key cell surface protein that binds TIM-4, leading to T cell proliferation and T helper type 2 (Th2) cytokine production. TIM-1 has also been shown to bind and activate macrophages.

Two splice variants for human TIM-1 exist; TIM-1a is predominantly expressed in the liver, whilst TIM-1b is expressed in the kidney. Expression of TIM-1 in the kidney is thought to be upregulated in damaged tissue, and is thought to assist healing.

TIM-1 polymorphisms are associated with asthma.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Purified

Preparation

Antisera to human TIM-1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Immunogen:
16 amino acid peptide sequence near the center of human TIM-1.
Preservative:
0.02%Sodium Azide

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Usage

This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.