Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Livin (BIRC7/ML-IAP) contains a single BIR domain and RING finger motif that is highly expressed in human melanomas and absent in normal tissues. It is localized in the nucleus and diffusely in the cytoplasm. The livin gene encodes two splicing variants, a 298 amino acid isoform (alpha) and a 280 amino acid form (beta), with different biological activity to various apoptotic stimuli. In addition to directly inhibiting caspase activity, livin can promote the degradation of the proapoptotic protein Smac through the ubiquitin-proteasome pathway.

This antibody can specifically bind to human Livin. The cross reactivity with mouse and rat Livin was not tested.

Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can also be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 30 days at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.