Rabbit Anti-Human MAPK7 (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q13164 |
| Gene Id | 5598 |
| Gene Symbols | MAPK7 |
| Protein Name / Synonyms | MAPK7 (C-term) |
| Clonality | Polyclonal |
| Preparation | This MAPK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 776-805 amino acids from the C-terminal region of human MAPK7. |
| Concentration (lot specific) | 1.200 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Angiogenesis, Inflammation, MAPK Signaling |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
MEK5 and ERK5, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
Specificity
Predicted Reactivity
Mouse, Rat, Bovine
Other Names
MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; Big MAP kinase 1; Extracellular signal-regulated kinase 5
NCBI Accession #
NP_002740.2;NP_620601.1;NP_620602.2;NP_620603.2
Other Accession #
P0C865; Q9WVS8; A5PKJ4
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
88386
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of anti-ERK5 C-term Pab (Cat# 102-17391) in K562 cell line lysates (35ug/lane). ERK5 (arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
 | Formalin-fixed and paraffin-embedded human kideny carcinoma tissue reacted with ERK5 Antibody (C-term) (Cat# 102-17391), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.