Rabbit Anti-Human MBNL1 (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9NR56 |
| Gene Id | 4154 |
| Gene Symbols | MBNL1 |
| Protein Name / Synonyms | MBNL1 (C-term) |
| Clonality | Polyclonal |
| Preparation | This MBNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human MBNL1. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
Specificity
Other Names
MBNL1; EXP; KIAA0428; MBNL; Muscleblind-like protein 1; Triplet-expansion RNA-binding protein
NCBI Accession #
NP_066368.2;NP_997175.1;NP_997176.1;NP_997177.1;NP_997178.1;NP_997179.1;NP_997180.1
Other Accession #
NP_066368.2
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
41817
Recommended Dilutions
WB: 1:1000
 | MBNL1 Antibody (C-term) (Cat# 102-14516) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MBNL1 antibody detected the MBNL1 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.