Rabbit Anti-Human MCSF Receptor (CSF1R) (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P07333 |
| Gene Id | 1436 |
| Gene Symbols | CSF1R |
| Protein Name / Synonyms | MCSF Receptor (CSF1R) (C-term) |
| Clonality | Polyclonal |
| Preparation | This MCSF Receptor (CSF1R) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-971 amino acids from the C-terminal region of human MCSF Receptor (CSF1R). |
| Concentration (lot specific) | 0.45 mg/ml |
| Recommended Applications | FC, Western Blotting, IHC-P |
| Research Area | Cancer, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
CSF1R is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. This protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.
Specificity
Other Names
CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; Proto-oncogene c-Fms; CD_antigen=CD115; Flags: Precursor
NCBI Accession #
NP_005202.2
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
107984
Recommended Dilutions
WB: 1:1000; FC: 1:10-50; IHC: 1:10-50
 | Western blot analysis of anti-CSF1R Pab (Cat# 102-17447) in human placenta. CSF1R (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. |
 | Western blot analysis of CSF1R (arrow) using rabbit polyclonal CSF1R Antibody (C-term)(Cat# 102-17447). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CSF1R gene (Lane 2) (Origene Technologies). |
 | MCSF Receptor (CSF1R) Antibody (C-term) (Cat# 102-17447) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
 | Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CSF1R Antibody (C-term) (Cat# 102-17447), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.