Rabbit Anti-Human NFKBIB (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q15653 |
| Gene Id | 4793 |
| Gene Symbols | NFKBIB |
| Protein Name / Synonyms | NFKBIB (C-term) |
| Clonality | Polyclonal |
| Preparation | This NFKBIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-355 amino acids from the C-terminal region of human NFKBIB. |
| Concentration (lot specific) | 0.310 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Specificity
Other Names
NFKBIB; IKBB; TRIP9; NF-kappa-B inhibitor beta; I-kappa-B-beta; Thyroid receptor-interacting protein 9
NCBI Accession #
NP_001230045.1;NP_002494.2
Other Accession #
NP_001001716.1; NP_002494.2
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
37771
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | NFKBIB Antibody (C-term) (Cat# 102-12160) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NFKBIB antibody detected the NFKBIB protein (arrow). |
 | NFKBIB Antibody (C-term) (102-12160)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NFKBIB Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.