Plasminogen Activator Inhibitor 1 (PAI-1)Also known as SERPINE1, a 45kDa serine protease inhibitorand member of the serpin family, which acts as the primary inhibitor of tissue plasminogen activator(tPA) and urokinase plasminogen activator (uPA), and hence fibrinolysis. Increased levels of PAI-1 areassociated with diabetes, cardiovascular disease and an increased occurrence of thrombosis in obesity,and can be induced by obesity related factors including insulin, glucose and VLDL (very-low-densitylipoprotein).

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

Rabbit Anti-Human PAI-1 antibody detects a target derived from a human recombinant PAI-1 protein aswell as selected cell lysates. Cross reactivity with mouse and rat PAI-1 was not determined.