Rabbit Anti-Human Phospho-TSC2(S939) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P49815 |
| Gene Id | 7249 |
| Gene Symbols | TSC2 |
| Protein Name / Synonyms | Phospho-TSC2(S939) |
| Clonality | Polyclonal |
| Preparation | This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S939 of human TSC2. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | IF, Dot Blotting |
| Research Area | Cardiovascular Disease, Autophagy |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Specificity
Predicted Reactivity
Mouse
Other Names
TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein
NCBI Accession #
NP_000539.2;NP_001070651.1;NP_001107854.1
Other Accession #
Q61037
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
200608
Recommended Dilutions
DB: 1:500; IF: 1:10-50
 | Dot blot analysis of anti-TSC2-pS939 Phospho-specific Pab (Cat.102-15416) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. |
 | Confocal immunofluorescent analysis of Phospho-TSC2-pS939 Antibody(Cat# 102-15416) with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.