Retinol-binding protein 4 (RBP4) is a small transport protein (~ 23 kDa) and belongs to the lipocalin family with diverse functions. It is the specific carrier protein for retinol (vitamin A alcohol) in the serum. It delivers retinol from the liver stores to the peripheral tissues. In human plasma, the RBPretinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. Recently, RBP4 was known to be one of adipokine secreted by adipocytes and relate to insulin resistance in the AG4KO mouse model. RBP4 may contribute to pathogenesis of type 2 diabetes. Yang et al. demonstrated that serum RBP4 levels are elevated in patients with obesity and type 2 diabetes.

The rabbit anti-human Retinol-binding protein 4 detects specifically target derived from recombinant protein as well as cellular proteins at various concentrations. Cross reactivity with mouse and rat are expected from sequence similarity.

Store at -20°C, if not intended for use within a month, Keep it at 4°C and minimize freezing and thawing when use.