Rabbit Anti-Human SDF-1 alpha / CXCL12a
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Anti-SDF-1 alpha / CXCL12a Antibody
| Size | 0.1 mg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | This product recognizes human SDF-1 alpha, otherwise known as CXCL12a, a 68 amino acid stromal cell derived CXC chemokine, which arises from alternative splicing of the SDF-1 gene. The two isoforms, SDF-1 alpha and SDF-1 beta, share an identical amino acid sequence, except for an additional four residues in the C-terminal region of the beta isoform. SDF-1 binds with high-affinity to the G protein❏❏coupled receptor CXCR4 (fusin) and acts as a chemoattractant for T and B lymphocytes, monocytes and migratory neurons, and is a vital factor in hematopoiesis and angiogenesis. By competitively binding to CXCR4, SDF-1 acts as an inhibitor for the CXCR4-mediated entry of HIV-1 virus into target T-cells, and the SDF-1-CXCR4 interaction is important for the regulation of trafficking of normal and malignant stem cells. |
| Host Species | Rabbit |
| Protein Name / Synonyms | SDF-1 alpha / CXCL12a |
| Preparation | Antisera to human SDF-1 alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography. |
| Concentration (lot specific) | IgG concentration 1.0 mg/ml after reconstitution. |
| Recommended Applications | ELISA (dilution: 0.1, 0.2ug/ml), Functional Assays, Immunohistology - Paraffin, Western Blotting |
| Reconstitution | Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not add azide. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
This product may be used under either reducing or non-reducing western blotting conditions.
Prior to reconstitution store at +4 °C.
After reconstitution store at -20 °C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.
Antisera to human SDF-1 alpha were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
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Anti-SDF-1 alpha / CXCL12a Antibody