Rabbit Anti-Human SRC8 (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q14247 |
| Gene Id | 2017 |
| Gene Symbols | CTTN |
| Protein Name / Synonyms | SRC8 (N-term) |
| Clonality | Polyclonal |
| Preparation | This SRC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human SRC8. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
SRC8 is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.
Specificity
Predicted Reactivity
Mouse, Chicken
Other Names
CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1
NCBI Accession #
NP_001171669.1;NP_005222.2;NP_612632.1
Other Accession #
Q60598; Q01406
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
61586
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of SRC8 Antibody (N-term) (Cat# 102-18203) in HL-60 cell line lysates (35ug/lane). SRC8 (arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human breast carcinoma with SRC8 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.