Rabbit Anti-Human SUV39H2 (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9H5I1 |
| Gene Id | 79723 |
| Gene Symbols | SUV39H2 |
| Protein Name / Synonyms | SUV39H2 (C-term) |
| Clonality | Polyclonal |
| Preparation | This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-390 amino acids from the C-terminal region of human SUV39H2. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
Specificity
Predicted Reactivity
Monkey
Other Names
SUV39H2; KMT1B; Histone-lysine N-methyltransferase SUV39H2; Histone H3-K9 methyltransferase 2; Lysine N-methyltransferase 1B; Suppressor of variegation 3-9 homolog 2
NCBI Accession #
NP_001180353.1;NP_001180354.1;NP_001180355.1;NP_001180356.1;NP_078946.1
Other Accession #
Q4R3E0; NP_078946
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
46682
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of anti-hSUV39H2-K315 Pab (Cat. 102-11748) in 293 and HL60 cell line lysates (35ug/lane). hSUV39H2-K315(arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.