Introduction
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
Specificity
Other Names
TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1
NCBI Accession #
NP_001265611.1;NP_001265613.1;NP_001265615.1;NP_003235.1;NP_733796.2;NP_775299.1;NP_775300.1;NP_775301.1;NP_775302.1;NP_775303.1;NP_777480.1
Other Accession #
NP_003235.1; NP_775299.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
43013
Recommended Dilutions
WB: 1:1000
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.