After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

WB 1:500 - 1:2000; IHC 1:50 - 1:200; IF 1:50 - 1:200

Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human INS (NP_000198.1).

Unmodified

Store at -20°. Avoid freeze / thaw cycles.