Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Livin (BIRC7/ML-IAP) contains a single BIR domain and RING finger motif that is highly expressed in human melanomas and absent in normal tissues. It is localized in the nucleus and diffusely in the cytoplasm. The livin gene encodes two splicing variants, a 298 amino acid isoform (alpha) and a 280 amino acid form (beta), with different biological activity to various apoptotic stimuli. In addition to directly inhibiting caspase activity, livin can promote the degradation of the proapoptotic protein Smac through the ubiquitin-proteasome pathway.

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

This antibody can specifically bind to human Livin. The cross reactivity with mouse and rat Livin was not tested.