Rabbit Anti-Mouse Irf3 (N-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse |
| Host Species | Rabbit |
| Accession Number | P70671 |
| Gene Id | 54131 |
| Gene Symbols | IRF3 |
| Protein Name / Synonyms | Irf3 (N-term) |
| Clonality | Polyclonal |
| Preparation | This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3. |
| Concentration (lot specific) | 0.350 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cardiovascular Disease, Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
Specificity
Predicted Reactivity
Bovine, Pig
Other Names
Irf3; Interferon regulatory factor 3
NCBI Accession #
NP_058545.1
Other Accession #
Q764M6; Q4JF28; NP_058545.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
46852
Recommended Dilutions
WB: 1:1000
 | MOUSE Irf3 Antibody (N-term) (Cat# 102-14538) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MOUSE Irf3 antibody detected the MOUSE Irf3 protein (arrow). |
Antigen Source
MOUSE
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.