Rabbit Anti-Mouse Myb Sumoylation Site Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse |
| Host Species | Rabbit |
| Accession Number | P10242 |
| Gene Id | 4602 |
| Gene Symbols | MYB |
| Protein Name / Synonyms | Myb Sumoylation Site |
| Clonality | Polyclonal |
| Preparation | This Myb Sumoylation Site antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from human Myb Sumoylation Site. |
| Concentration (lot specific) | 0.320 mg/ml |
| Recommended Applications | IHC-P, Western Blotting |
| Research Area | Cardiovascular Disease, Post-Translational Modifications |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Myb is a transcriptional activator; DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.
Specificity
Other Names
MYB; Transcriptional activator Myb; Proto-oncogene c-Myb
NCBI Accession #
NP_001123644.1;NP_001123645.1;NP_001155128.1;NP_001155129.1;NP_001155130.1;NP_001155131.1;NP_001155132.1;NP_005366.2
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
72341
Recommended Dilutions
IHC: 1:50-100; WB: 1:1000
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
 | Myb Antibody (Sumo) (Cat# 102-15038) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Myb antibody detected the Myb protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.