Anti-Phospho-BRCA1-S1423 Antibody

Phospho-BRCA1-S1423 Polyclonal Antibody
As low as $211.00
In stock
Only %1 left

Product Description


Size 50 ul, 100 ul, 200 ul
Species Human, Mouse, Rat
Host Species Rabbit
Isotype Igg
Buffers 50% glycerol, PBS with 0.02% sodium azide, pH7.3.
Protein Name / Synonyms BRCA1, BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53, BRCA1, DNA repair associated
Accession Number P38398
Gene Symbols BRCA1
Gene Id 672
Purity Affinity purification


This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.


WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200


Calculated MW
Observed MW


A synthetic phosphorylated peptide around S1423 of human BRCA1 (NP_009225.1).


Phospho S1423




Western blot analysis of extracts of HT-29 cells,using Phospho-BRCA1-S1423 antibody (144-50232) at 1:2000 dilution. HT-29 cells were treated by Anisomycin (5ug/ml) for 30 minutes after serum-starvation overnight.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
Detection: ECL Basic Kit.
Exposure time: 5s.
Western blot - Phospho-BRCA1-S1423 pAb (144-50232)

Immunohistochemistry of paraffin-embedded rat liver using Phospho-BRCA1-S1423 antibody (144-50232) at dilution of 1:100 (40x lens).
Immunohistochemistry - Phospho-BRCA1-S1423 pAb (144-50232)

12 months from the date of shipment when stored properly.
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