Rabbit Anti-TDG (C-term) Antibody, 400 µl
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q13569 |
| Gene Id | 6996 |
| Gene Symbols | TDG |
| Protein Name / Synonyms | G/T mismatch-specific thymine DNA glycosylase, Thymine-DNA glycosylase, hTDG, TDG |
| Clonality | Polyclonal |
| Clone | RB19894 |
| Isotype | Kappa, Rabbit |
| Recommended Applications | Western Blotting, FC |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
The protein TDG belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.
Other Information
NCBI Accession #
NP_003202.3
Antigen Type
Synthetic Peptide
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Calculated Molecular Weight (Da)
46053
Antigen Source
Human
Images
WB (1:1000)
Western blot analysis of TDG antibody (C-term) (Cat. #102-27060) in K562 cell line lysates (35ug/lane). TDG (arrow) was detected using the purified Pab.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.