Thrombospondin 1 (TSP-1) is a glycoprotein that is released from platelet alpha-granules in response to thrombin stimulation and is also a transient component of the extracellular matrix in developing and repairing tissues. TSP-1 is a subunit of a disulfide-linked homotrimeric protein. TSP-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. TSP-1 can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Medical interest in thrombospondin-1 focuses on its roles in haemostasis and its effects on angiogenesis.

This antibody recognizes human TSP-1. Cross reactivity with mouse and rat TSP-1 was detected.

Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1 month at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.