This antibody recognizes the murine antigen ER-MP58, which is expressed by all bone marrow-derived M-CSF- and GM-CSF-responsive myeloid blood cell precursors.

The expression of ER-MP58 remains at a high level throughout the precursor/monocyte stage and is down-regulated upon maturation into mature macrophages. The ER-MP58 antigen is used to distinguish between early myeloid-committed cells and other hematopoietic progenitors cells in the BM. The antigen has been used as a marker of murine macrophage development in the BM.

ER-MP58 is suitable for the identification of myeloid hemopoietic islands in various organs, and for embryonal studies.

IgG concentration 1.0 mg/ml