The NF-kB-like transcription factor Relish plays a central role in the innate immune response of Drosophila. Relish is a bipartite NF-kB precursor protein, with an N-terminal Rel homology domain and a C-terminal IkappaB-like domain, similar to mammalian p100 and p105. Unlike mammalian NF-kB proteins, Relish is activated by endoproteolytic cleavage to generate a DNA-binding Rel homology domain (545 a.a.) and a stable IkB-like fragment (426 a.a.).

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

The antibody detects specifically target peptide derived from Drosophila Relish by ELISA and Dot Blotting. Also detects cleaved and uncleaved Relish in PFA-fixed Drosphila tissue (see image). Cross reactivity with human, mouse and rat have not been tested.