Choose Your Approach:
Multiplex DDR Antibody Arrays
The Human DDR Phosphorylation Array kit is an easy-to-use membrane format for detecting DDR signaling in cells or tissues, with no need for multiple Western blots. Targets include phosphorylated C-ABL, CDC2, CHK1, CHK2, Cyclin B1, H2AX, NBS1, p53, cleaved PARP, and more. Also available as a mouse-specific kit.
For broader biomarker discovery, the Human DNA Damage Biomarker Screening Array is a glass slide array profiling 308 DNA damage-related targets in a single assay. For a more affordable and targeted readout, the Human DNA Damage Response Array C1 is a semi-quantitative membrane array detecting 27 key DDR markers.
Sample Types: cultured cell or tissue extracts.
Mitochondrial DNA Damage Assays
The Mitochondrial DNA Damage Quantification kits are qPCR-based assays that detect the accumulation of lesions in mtDNA — a suspected driver of energy crisis in aging or diseased tissues. These assays are available for human, mouse, or rat-derived DNA, and target the long mtDNA D-Loop region, which is most susceptible to damage.
Sample Types: genomic DNA from cultured cells, tissue, saliva, scraped cells, urine, blood, lavage, spinal or other fluids.
DNA Damage Gene Expression Array
The Human DNA Damage & Repair qPCR Array is a SYBR Green-based qPCR assay that profiles 89 validated genes across DDR and repair pathways on a single 96-well plate. Built-in reference, genomic DNA, positive, and negative controls help ensure reliable results in as little as two hours.
Sample Type: cDNA generated from extracted RNA.
Phosphorylation ELISAs
ELISAs offer a convenient way to detect individual phosphorylated signaling molecules within DDR pathways. The 96-well format allows higher-throughput analysis than traditional immunoblotting. Browse a complete list of DDR-related phospho-specific ELISA kits, including p53, H2AX, c-Abl, and more.
Sample Types: cultured cell or tissue extracts.
DNA Damage Proteins
Recombinant DNA damage proteins, including p53, RAD51, CHK2, and MDC1, are available as standards, immunoassay controls, or functional tools for your DDR molecular studies.