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Anti-Activin-A Antibody
Catalog #: 130-10022
Rabbit Anti-Human Activin-A Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Accession Number | P27092 |
| Gene Id | 396361 |
| Gene Symbols | INHBA |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from human Activin A. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation, and followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CKKQFFVSFKDIGWNDWIIAPSGYH |
| Recommended Applications | ELISA (recommended work dilution= 1:8, 000(at least detecting 125ng/ml)) |
| Reconstitution | Supplied as lyophilized and purified antibody originally containing PBS, without Preservative Stabilizers, such as Sodium Azide. The final concentration is indicated on the shipping vial. The antibody is stable for at least years from the data of receipt when stored at -20°C to -70°C. Reconstituted antibody (recommended with H20 1 mg/ml) can also be aliquoted and stored frozen at -20°C to -70°C in a manual defrost freezer for months without detectable loss activity. Upon reconstitution, the antibody can also be stored over months at 4°C. Please avoid freeze-thaw cycles. |
| Research Area | TGF-beta Signaling |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Inhibins and Activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. They are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may play a role in regulating neurotransmitter phenotype.
Specificity
The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat Activin A has not yet been tested.
Storage
Store at -20°C, if not intended for use within a month, keep it at 4°C and minimize freezing and thawing when use.
Related Products
Custom Human Activin A ELISA Kit available on demand (Cat# ELH-ActivinA-001 ) Recombinant Human Activin-A (Cat#228-10022-1 ) RayBio® Human Cytokine Array 10 Service(Cat#AAH-SERV )
References
- McLean AB, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells. 2007;25(1):29-38.
- Semitekolou M,et al. Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J Exp Med. 2009 Aug 3;206(8):1769-85.
Expiration:
12 months from the date of shipment when stored properly.