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Anti-Activin-A Antibody, Biotinylated
Catalog #: 130-10022B-50
Rabbit anti-Activin-A Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P27092 |
| Gene Id | 396361 |
| Gene Symbols | INHBA |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from human Activin A. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation, and followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CKKQFFVSFKDIGWNDWIIAPSGYH |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1:8, 000(at least detecting 125 µg/ml)) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Research Area | TGF-beta Signaling |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Inhibins and Activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. They are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may play a role in regulating neurotransmitter phenotype.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat Activin A has not yet been tested.
Related Products
Custom Human Activin A ELISA Kit available on demand (Cat# ELH-ActivinA-001 ) Recombinant Human Activin-A (Cat#228-10022-1 ) RayBio® Human Cytokine Array 10 Service(Cat#AAH-SERV )
References
- McLean AB, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells. 2007;25(1):29-38.
- Semitekolou M,et al. Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease. J Exp Med. 2009 Aug 3;206(8):1769-85.
Expiration:
12 months from the date of shipment when stored properly.