Anti-Activin Receptor Type IA (ACVR1) (Center N99) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q04771
Gene Id	90
Gene Symbols	ACVR1
Protein Name / Synonyms	Activin Receptor Type IA (ACVR1) (Center N99)
Clonality	Polyclonal
Preparation	This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-123 amino acids from the Central region of human Activin Receptor Type IA (ACVR1).
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease, Inflammation, TGF-beta Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.

Specificity

Predicted Reactivity

Bovine

Other Names

ACVR1; ACVRLK2; Activin receptor type-1; Activin receptor type I; Activin receptor-like kinase 2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I

NCBI Accession #

NP_001096.1;NP_001104537.1

Other Accession #

P37172; Q28041

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

57153

Recommended Dilutions

WB: 1:1000

	Western blot analysis of anti-ACVR1 Pab (Cat# 102-17130) in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified Pab.
	ACVR1 Antibody (N-term) (Cat# 102-17130) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the ACVR1 antibody detected the ACVR1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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