Anti-ADAMTS4 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	O75173
Gene Id	9507
Gene Symbols	ADAMTS4
Protein Name / Synonyms	ADAMTS4 (C-term)
Clonality	Polyclonal
Preparation	This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-736 amino acids from the C-terminal region of human ADAMTS4.
Concentration (lot specific)	0.250 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Specificity

Other Names

ADAMTS4; KIAA0688; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADMP-1; Aggrecanase-1

NCBI Accession #

NP_005090.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

90197

Recommended Dilutions

WB: 1:1000

Western blot analysis of anti-ADAMTS4 Antibody (C-term)(Cat# 102-17346) in mouse cerebellum tissue lysates (35ug/lane). ADAMTS4 (arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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