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Anti-Adiponutrin (C-term) Antibody
Catalog #: RB-08-0033
Rabbit Anti-Human Adiponutrin (C-terminus) Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Accession Number | NM_025225 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was a synthetic peptide derived from Human Adiponutrin. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum by ammonium sulphate precipitation followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CLSERAPHLLRDARTFFGD |
| Recommended Applications | ELISA (recommended work dilution= 1:1, 000-64, 000 (at least detecting 2-5 ng/ml)) |
| Reconstitution | Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Adiponutrin, designated as ADPN is a 53 kDa member of the PNPLA family of phospholipase A2 enzymes. It also is called as PNPLA3, patatin-like phospholipase domain-containing protein 3. ADPN is expressed in white adipocytes. Very importantly, it is a predominantly liver-expressed transmembrane protein with phospholipase activity that is regulated by fasting and feeding. Recent genome-wide association studies identified PNPLA3 to be associated with hepatic fat content and liver function, thus pointing to a possible involvement in the hepatic lipoprotein metabolism. Investigation also demonstrated that adiponutrin could be involved in vesicular targeting and protein transport restricted to the adipocyte function.
Specificity
Human Adiponutrin C-Terminus. Cross reactivity with mouse and rat are expected from sequence similarity.
Expiration:
12 months from the date of shipment when stored properly.