Anti-Androgen Receptor (ANDR) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P10275
Gene Id	367
Gene Symbols	AR
Protein Name / Synonyms	Androgen Receptor (ANDR)
Clonality	Polyclonal
Preparation	This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR).
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Apoptosis, Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor; sumoylation of ANDR represses androgen receptor dependent transcription.

Specificity

Predicted Reactivity

Pig, Monkey

Other Names

Androgen receptor; AR

NCBI Accession #

NP_000035.2;NP_001011645.1

Other Accession #

Q9GKL7; P19091; O97952; Q5JUN9

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

98989

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	ANDR (Cat# 102-15042) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the AR antibody detected the AR protein (arrow).
	ANDR Antibody (Sumo-site) (Cat# 102-15042) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the ANDR antibody detected the ANDR protein (arrow).
	Androgen Receptor Antibody (ANDR) (Cat# 102-15042)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Androgen Receptor Antibody (ANDR) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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