3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-ANTXR1 (Y382) Antibody
Catalog #: 102-17600
Rabbit Anti-Human ANTXR1 (Y382) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9H6X2 |
| Gene Id | 84168 |
| Gene Symbols | ANTXR1 |
| Protein Name / Synonyms | ANTXR1 (Y382) |
| Clonality | Polyclonal |
| Preparation | This ANTXR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-386 amino acids from human ANTXR1. |
| Concentration (lot specific) | 0.500 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Specificity
Predicted Reactivity
Mouse, Rat
Other Names
ANTXR1; ATR; TEM8; Anthrax toxin receptor 1; Tumor endothelial marker 8
NCBI Accession #
NP_060623.2;NP_115584.1;NP_444262.1
Other Accession #
Q6DFX2; P58335; Q0PMD2; Q9CZ52
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
62789
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of anti-ANTXR1 Antibody (Y382)(Cat# 102-17600) in Hela cell line lysates (35ug/lane). ANTXR1 (arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ANTXR1 Antibody (Y382) (Cat# 102-17600), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.