Rabbit Anti-Human APOE (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P02649 |
| Gene Id | 348 |
| Gene Symbols | APOE |
| Protein Name / Synonyms | APOE (C-term) |
| Clonality | Polyclonal |
| Preparation | This APOE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human APOE. |
| Recommended Applications | Western Blotting, IHC-P |
| Research Area | Inflammation |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III),in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Specificity
Predicted Reactivity
Monkey, Rabbit
Other Names
APOE; Apolipoprotein E
NCBI Accession #
NP_000032.1
Other Accession #
P18287; P10517
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
36154
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of lysate from human blood plasma tissue lysate, using APOE Antibody (C-term)(Cat# 102-17435). 102-17435 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. |
 | Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with APOE antibody (C-term) (Cat# 102-17435), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.