Anti-AR (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P10275
Gene Id	367
Gene Symbols	AR
Protein Name / Synonyms	AR (Center)
Clonality	Polyclonal
Preparation	This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 amino acids from the Central region of human AR.
Concentration (lot specific)	0.330 mg/ml
Recommended Applications	Western Blotting
Research Area	Apoptosis, Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].

Specificity

Predicted Reactivity

Monkey

Other Names

AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4

NCBI Accession #

NP_000035.2;NP_001011645.1

Other Accession #

O97952; NP_001011645.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

98989

Recommended Dilutions

WB: 1:1000

AR Antibody (Center) (Cat# 102-11850) western blot analysis in NCI-H292,NCI-H460 cell line lysates (35ug/lane).This demonstrates the AR antibody detected the AR protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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