Anti-ARH (LDLRAP1) (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q5SW96
Gene Id	26119
Gene Symbols	LDLRAP1
Protein Name / Synonyms	ARH (LDLRAP1) (N-term)
Clonality	Polyclonal
Preparation	This ARH (LDLRAP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-42 amino acids from the N-terminal region of human ARH (LDLRAP1).
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

Specificity

Predicted Reactivity

Mouse

Other Names

LDLRAP1; ARH; Low density lipoprotein receptor adapter protein 1; Autosomal recessive hypercholesterolemia protein

NCBI Accession #

NP_056442.2

Other Accession #

Q8C142

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

33885

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of LDLRAP1 Antibody (N-term) (Cat# 102-17755) in K562 cell line lysates (35ug/lane). LDLRAP1 (arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with LDLRAP1 antibody (N-term) (Cat# 102-17755), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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