Anti-ARHE (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P61587
Gene Id	390
Gene Symbols	RND3
Protein Name / Synonyms	ARHE (Center)
Clonality	Polyclonal
Preparation	This ARHE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-165 amino acids from the Central region of human ARHE.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors. Like Ras (MIM 190020), Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925); GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855); and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998 [PubMed 9531558]).

Specificity

Predicted Reactivity

Rat, Pig

Other Names

RND3; ARHE; RHO8; RHOE; Rho-related GTP-binding protein RhoE; Protein MemB; Rho family GTPase 3; Rho-related GTP-binding protein Rho8; Rnd3

NCBI Accession #

NP_001241667.1;NP_005159.1

Other Accession #

Q6SA80; O77683; P61588

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

27368

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of ARHE Antibody (Center)(Cat. 3102-17601) in mouse brain tissue lysates (35ug/lane). ARHE (arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ARHE antibody (Center) (Cat# 102-17601), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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