Anti-ATXN1 (S776) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P54253
Gene Id	6310
Gene Symbols	ATXN1
Protein Name / Synonyms	ATXN1 (S776)
Clonality	Polyclonal
Preparation	This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.
Concentration (lot specific)	0.410 mg/ml
Recommended Applications	Western Blotting, IF
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.

Specificity

Other Names

ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein

NCBI Accession #

NP_000323.2;NP_001121636.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

86923

Recommended Dilutions

WB: 1:1000; IF: 1:10-50

	Western blot analysis of anti-ATXN1 Antibody (S776) (Cat# 102-15155) in CEM cell line lysates (35ug/lane). ATXN1 (arrow) was detected using the purified Pab.
	Confocal immunofluorescent analysis of ATXN1 Antibody (S776)(Cat# 102-15155) with hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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